hordhac
Gorelatide, oo sidoo kale loo yaqaan n-acetyl-serine - aspartic acid - proline - proline -(N-Acetyl-Ser-Asp-Lys-Pro), oo loo soo gaabiyo Ac-SDKP, waa tetrapeptide endogenous, nitrogen end acetylation, si ballaaran loo qaybiyey unugyo kala duwan iyo dheecaannada jidhka ee jirka.Tetrapeptide-kan waxa sii daaya prolyl oligopeptidase (POP), kaas oo inta badan uu keeno thymosin horudhac ah.U fiirsashada dhiiga ku jirta badiyaa waa miisaanka nanomole.
okinetics
Marka loo eego daraasadda farmashiyaha ee Gorelatide, ka dib cirbadeynta xididada, Gorelatide waxay si dhakhso ah u hoos u dhigtaa nolosha nuska ah ee kaliya 4 ~ 5min.Gorelatide waxaa laga nadiifiyaa balasmaha bini'aadamka laba hab:①Angiotensin-converting enzyme (ACE) -Hydrolysis hanuunsan;②Sifeynta Glomerular.Hydrolysis ee angiotensin beddelidda enzyme (ACE) waa dariiqa ugu muhiimsan ee dheef-shiid kiimikaadka gorelatide.
Dhaqdhaqaaqa noolaha
Gorelatide waa nooc ka mid ah qodobbada nidaaminta jireed ee hawlqabad badan leh oo leh hawlo bayooloji oo kala duwan.Horay ayaa loo sheegay in Gorelatide ay ka hortagi karto gelitaanka unugyada tarma ee hematopoietic ee asalka ah ee marxaladda S oo ay ka dhigaan kuwo taagan wejiga G0, oo xannibaya dhaqdhaqaaqa unugyada tarma ee hematopoietic.Intaa ka dib waxaa la ogaaday in Gorelatide ay wanaajin karto awoodda dib-u-beerista epidermalka iyadoo kor u qaadeysa samaynta xididdada dhiigga waxayna dardargelisaa bogsashada nabarrada xididdada xididdada dhiigga ee dhaawacan.Gorelatide waxay joojin kartaa kala soocida unugyada tarma ee dhuuxa lafta oo ay kicisay MGM ee macrophages, sidaas darteed waxay ciyaaraysaa doorka ka hortagga bararka.Gorelatide ayaa dhawaan la ogaaday in ay joojiso faafinta unugyo kala duwan.
isticmaal
Sida maadada dabiiciga ah ee polypeptide, Gorelatide waxaa loo isticmaali karaa sida alaab cayriin ah.
Waqtiga boostada: Abriil-26-2023