Peptide khaas ahSynthesisAdeegga
Hangzhou Go Top Peptide Biotech , oo la aasaasay 2014, waa a National High-tech Enterpriseku takhasusay cilmi-baarista, horumarinta iyo soo saarista peptides iyo waxyaabaha la xiriira.
Shirkaddaxarunta cilmi baarista peptidehadda waxay ku taal Degmada Qiantangof Hangzhou, oo daboolaysa dhul ka badan 3,000 mitir oo laba jibbaaran.Theshirkad's warshad waxay ku taal No.24, Haitian Road, Degmada Shangyu, magaalada Shaoxing, gobolka Zhejiang.Waxaa kaloo jira laba warshadood oo iskaashi, mid ayaa loogu talagalaywax soo saarka peptide GMP ganacsi ku yaalGobolka Anji ee gobolka Zhejiang, mid waa API molecule yar oo ku yaalMagaalada Yuncheng ee gobolka Shanxi.Waxaan noqonayganacsi heer sare ah oo dhamaystiran, midaynta cilmi-baarista, kor u qaadista tijaabada, ganacsi-is-weydaarsiga iyo iibinta caalamiga ah.
Shirkaddu waxay leedahaydhaaftay100shaqaalaha,oo uu leeyahayhorumaray in ka badan40 dawooyinka qaangaarka ahpeptides,in ka badan10 shati-hal-abuurnimola oggolaaday.Tawoodda wax soo saarka sanadlaha ahis ilaa100 kiiloogaraam, tirada peptides caadadii leedahay gaaray in ka badan 20,000.Waxaan bixin karnaa adeegyada peptide-ka hal-joojin laga bilaabo cilmi-baarista (mg) ilaa ganacsi-abuurista (KGs).
Liiska Wax ka beddelka Peptide
N-wax ka beddelka terminalka
| {N-Me-Ala} | {N-Me-Asp} | {N-Me-Glu} | {N-Me-Ile} |
| {N-Me-Leu} | {N-Me-Met} | {N-Me-Nle} | {N-Me-Nva} |
| {N-Me-Phe} | {N-Me-Ser} | {N-Me-Thr} | {N-Me-Tyr} |
| {N-Me-Val} | {Sar} | N-Me-Arg | N-Me-Asn |
| N-Me-beta-Ala | N-Me-Gln | N-Me-Lys | N-Me-Trp |
C-wax ka beddelka terminalka
| {Mono Disulfide buundada} | {Buundada Disulfide-ka ah ee laba jibaaran} | {Briijka Triple Disulfide} |
| {Briijka Disulfide Random} | {Isla Seq.Buundada Inter-Disulfide } | {Briijka Inter-Disulfide kala duwan} |
| {Amide cycle (dhammaadka)} | {Amide cyclic (Side Side)} | { Silsiladda dhinaca Orn Amide cyclic} |
| {Thioester wareeg ah} | {lactone cycle} | {wareegga labaad} |
Amino acids aan caadi ahayn
| {2-Aze} | {3-Aze} | {5,5-Dime-Pro} |
| {5-ASA} | {Abuu} | {Ac-Lys} |
| {Aayb} | {Beta-Asp} | {Bpa} |
| {Cha} | {Chg} | {Cit} |
| {Cpg} | {Cys(Acm)} | {Cys(Bzl)} |
Isotope waxay ku calaamadsan tahay peptides
| Lys (13C6,15N2) | Ile(13C6,15N) |
| Leu(13C6,15N) | Val(13C5, 15N) |
| Arg (13C6, 15N4) |
Wax ka beddelka peptide fluorescent/lammaanaha FRET
| Biotin- | Dansyl- | peptide fluorecent oo la demiyay |
| Biotin-Ahx- | Dansyl-Ahx- | Dabcyl |
| 5-FAM- | Cy3- | Dabcyl / Glu(Edans)-NH2 |
| 5-FAM-Ahx- | Cy5- | Dansyl- |
| FITC- | MCA/DNP | Dansyl-Ahx- |
| FITC-Ahx- | AMC | Edans / Dabcyl |
Peptide Conjugates
| BSA (-COOH of C terminal | KLH(-NH2 ee N terminalka) | OVA(-COOH of C terminal) |
| Isku xirka BSA ee Cys | Isku xirka KLH ee Cys | OVA(-NH2 ee N terminal) |
| Isku xidhka OVA on Cys |
Fosfooraska
| {pSer} | {D-pSer} |
| {pTyr} | {D-pTyr} |
| {pThr} | {D-pThr} |
Waxka bedelka kale (PEGylation, Beddelka Wareegga, Buundooyinka Disulfide)
| PEGylation | Wax ka beddelka meerto | Buundooyinka Disulfide |
| {Mini-PEG1} | Madax ilaa dabada wareeg | {Mono Disulfide buundada} |
| {Mini-PEG2} | {Buundada Disulfide-ka ah ee laba jibaaran} | |
| {PEG-11} | {Briijka Triple Disulfide} | |
| {PEG-12} | {Briijka Disulfide Random} | |
| …… | …… | …… |