L-carnosine waa unug yar oo leh qaab-dhismeedka L-qaabeeya ee dipeptide dabiiciga ah kaas oo inta badan laga helo dabeecadda wuxuuna ka kooban yahay qaab-dhismeedyada dipeptide L-qaabeeya oo caadi ahaan laga helo dabeecadda.Dipeptide ka kooban β-alanine iyo L-histidine.Carnosine waxay leedahay noocyo kala duwan oo ah antioxidant-ka gacanta, ka-hortagga gabowga iyo daryeelka caafimaadka jireed iyo saameynaha caafimaad, sida hypertension, cudurada wadnaha, cataract ee waayeelka, soo kabashada boogaha, ka hortagga burooyinka, baaritaanka qaabka difaaca, arrimaha ka hortagga cadaadiska iyo wixii la mid ah.
Doorka
Carnosine waa carnosine oo uu helay saynisyahan Ruush ah Gulevich oo ay weheliso carnitine.Ingiriiska, Kuuriya, Ruushka, iyo Shiinaha kale, daraasado ayaa muujiyay in carnosine ay leedahay awood adag oo antioxidant ah oo faa'iido u leh bini'aadamka.Carnosine ayaa lagu muujiyey inay meesha ka saarto noocyada ogsijiinta falcelinta (ROS) oo ay samaysay oksaydhyo xad-dhaaf ah oo asiidh dufan ah oo ku jira xuubka unugyada inta lagu jiro diiqada oksaydhka, iyo sidoo kale α-β aldehyde aan lahayn.
Daraasado badan ayaa lagu ogaaday in N-acetylcarnosine ay saameyn wanaagsan ku leedahay ka hortagga iyo daaweynta cataract.Mid ka mid ah daraasaddan ayaa muujisay in carnosine ay hagaajisay cataracts oo ay sababtay opacities crystalline ee jiirka oo ay keentay soo-gaadhista guanidine.Inkasta oo sheegashooyinkani ay taageeraan tiro faa'iidooyin mala awaal ah oo isha ah sida daaweynta carnotin ee cataracts, waxay ilaa hadda, aan si buuxda u taageerin bulshada caafimaadka guud.Royal Orthopedics, tusaale ahaan, waxay sheegteen in carnosine uusan ahayn mid badbaado leh ama wax ku ool ah daaweynta maqaarka indhaha.
Sida laga soo xigtay warbixin 2002, carnosine waxay hagaajin kartaa xiriirka bulshada iyo kordhinta erayada ay isticmaalaan carruurta autismka qaba, laakiin hagaajinta lagu sheegay daraasadda waxay sidoo kale ka iman kartaa hagaajin, placebo, ama arrimo kale oo aan lagu qorin sahankan.
Habka isku-dhafka
Waqtigan xaadirka ah, hababka wax soo saarka ee carnosine waxay leeyihiin qaar ka mid ah cilladaha caadiga ah: sababtoo ah xaddidaadda falcelinta dhinaca, falcelinta dhinacan waxaa lagu fuliyaa ka qaybgalka giraanta L-histidine imidazole.L-histidine waxay u rogi doontaa ugu yaraan 0.8% habka falcelinta, hoos u dhigista wax soo saarka;Isla mar ahaantaana, way adag tahay in la kala saaro L-carnosine oo leh nadiif nadiif ah oo saafi ah oo nadiif ah oo ka soo jeeda isku-darka waxyeellada leh (qaabkeeda wareegga, isomers imidazole, iwm.), saameynaya nadiifnimada ganacsiga, sababtoo ah isku-dhafkan waxay leeyihiin sifooyin physicochemical la mid ah L-carnosine.Sababtoo ah joogitaanka isku-dhafkan, natiijada L-carnosine waa sun, halkii ay ka ahaan lahayd diyaarinta asalka ah ee asalka ah.
Habka cusub ee wax soo saarka L-carnosine waa sida soo socota: phthalic anhydride waxay ka falcelisaa β-alanine oo leh phthalic anhydride β-phthaloylanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine ilaa phthaloyl-alanine β-alanyl chloride;Xarunta ilaalinta L-trialkylsilane waxay la falgashaa trialkylchlorosilane ama hexahydroxysilane, waxay la falgashaa uumi phthalyl β-alanyl chloride hydrochloride, waxay ka saartaa kooxda difaaca ee khamriga anhydrous, iyo synthetates hydrochloride ee xalalka alkaline si ay u helaan wax soo saarka dhexdhexaadka ah, hydrazine hydrochloride. L-carnosine ee khamriga anhydrous.Alaabtani waa giraanta imidazole ee histidine-ka ilaalisa si looga fogaado dhibaatooyinka soo raaca ee giraanta imidazole ee L-histidine iyo walxaha kale, iyo helitaanka L-carnosine saafi ah oo leh waxyeelo hoose iyo wadarta guud ee dhalidda iyo nuxurka.
Waqtiga boostada: Oct-24-2023