Fosforyaalku waxay saameeyaan dhammaan dhinacyada nolosha gacanta, iyo kinase borotiinku waxay saameeyaan dhammaan dhinacyada hawlaha isgaarsiinta unugga iyadoo nidaaminaya waddooyinka calaamadaha iyo hababka gacanta.Si kastaba ha ahaatee, fosforyaalka aberrant ayaa sidoo kale ah sababta cudurro badan;gaar ahaan, kinase protein-ka is-beddelay iyo phosphatases-ku waxay sababi karaan cudurro badan, iyo sunno badan oo dabiici ah iyo cudur-sidaha ayaa sidoo kale saameyn ku leh iyagoo beddelaya heerka fosforyaalka ee borotiinnada unugyada gudaha.
Phosphorylation of serine (Ser), threonine (Thr), iyo tyrosine (Tyr) waa habka borotiinka wax ka beddelka ah.Waxay ku lug leeyihiin nidaaminta hawlo badan oo gacanta ah, sida calaamadaha soo-dhoweynta, ururka borotiinka iyo qaybinta, firfircoonida ama joojinta shaqada borotiinka, iyo xitaa badbaadada unugyada.Phosphates si taban ayaa loo dallacay (laba kharash oo taban koox kasta oo fosfate ah).Sidaa darteed, ku-darkoodu wuxuu beddelaa sifooyinka borotiinka, kaas oo badanaa ah isbeddel qaabaysan, taasoo keenta isbeddel ku yimaada qaab-dhismeedka borotiinka.Marka kooxda fosfooraska la saaro, isku-dhafka borotiinku wuxuu ku soo laaban doonaa sidii hore.Haddii labada borotiin ee is-dhafan ay muujiyaan hawlo kala duwan, fosforyaalku waxay u dhaqmi kartaa sidii beddelka molecular ee borotiinku si uu u xakameeyo dhaqdhaqaaqiisa.
Hormoonno badan ayaa habeeya dhaqdhaqaaqa enzymes gaar ah iyaga oo kordhinaya xaaladda fosforyaalka ee serine (Ser) ama threonine (Thr) hadhaaga, iyo tyrosine (Tyr) fosforyaalka waxaa kicin kara arrimo koritaanka (sida insulin).Kooxaha phosphate ee acids amino-kan si degdeg ah ayaa looga saari karaa.Sidaa darteed, Ser, Thr, iyo Tyr waxay u shaqeeyaan sida furayaasha molecular ee nidaaminta hawlaha gacanta sida faafinta burada.
peptides synthetic ayaa door aad u faa'iido leh ka ciyaara daraasadda borotiinka kinase substrates iyo isdhexgalka.Si kastaba ha ahaatee, waxaa jira arrimo qaar oo caqabad ku ah ama xaddidaya la qabsiga tignoolajiyada isku-dhafka fosfopeptide, sida awood la'aanta in la gaaro otomaatig buuxa ee isku-darka wejiga adag iyo la'aanta xiriir ku habboon oo leh aaladaha falanqaynta caadiga ah.
Qalabka ku salaysan peptide-ka iyo tignoolajiyada wax ka beddelka fosfooraska ayaa ka gudubta xaddidaadyadan iyada oo la hagaajinayo waxtarka isku-dhafka iyo xajmiga, iyo madalku wuxuu si fiican ugu habboon yahay daraasadda borotiinka kinase substrates, antigens, molecules-ka, iyo xannibayaasha.
Waqtiga boostada: Meey-31-2023