Dulmarka iyo isticmaalka cerulein

Dulmar

Caerulein, oo sidoo kale loo yaqaano cerulein, waa maqaar laga soosaaray haragga HYlacaerulea ee raha Australia oo ka kooban 10 amino acids.Waa molecule decapeptide ah oo ay bixiso trifluoroacetate taas oo u shaqeysa sida analoogga cholecystokinin ee unugyada vesicular ee ganaca waxayna u horseedi kartaa dheecaanka tiro badan oo enzymes dheefshiidka ah iyo casiirka ganaca, taasoo keenta pankreati barar ba'an.Cerutin waxaa loo isticmaali karaa in lagu barto Nf-κb kor u-qaadista borotiinka sida molecule adhesion molecule-1 (ICAM-1) arrimo la xiriira caabuqa sida NADPH oxidase iyo Janus kinase dhexdhexaadinta calaamadaynta.Waxaa si guul leh loo isticmaalay in lagu dhiso moodooyinka pankreatit ba'an ee jiirka, jiirarka, eyda, iyo hamsters Suuriya (AP).Dheecaannada faleebada ayaa sida ugu wanaagsan loo maamulaa xididka, maqaarka, ama cirbadeynta intraperitoneal.Waxaa si weyn loogu isticmaalaa tijaabooyinka kiliinikada ee pankreatit bararka ba'an, iyo tijaabooyinka in vitro ayaa lagu dabaqaa moodooyinka unugyada.Intaa waxaa dheer, waxaa loo isticmaalaa baaritaanka shaqada xameetida.

Dulmarka iyo isticmaalka cerulein

Macluumaad faahfaahsan

Muuqaal: budo cad

Lambarka CAS: 17650-98-5

Gutuo No. : GT-F055

Taxanaha: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Qaaciddada molecular: C58H73N13O21S2

Miisaanka unugyada: 1352.4

Solubility: Waxa lagu milmay 50mM ammonium hydroxide marka la eego 1.0mg/ml

Codsiga

1. Waxaa si weyn loogu isticmaalaa qaabaynta ee pankreatit bararka ba'an ee tijaabooyinka bukaan-socodka.

2. Codsiga moodooyinka unugyada in vitro.

3. Loo isticmaalo baaritaanka shaqada xameetida.

Si loo horumariyo qaabka daraasadda pankreatit ba'an ee daraasadda bayoolajiga unugyada cerulein (AP), sifooyinka pathophysiological iyo muujinta cudurrada organic ee pankreatit ba'an.Marka lagu daro baaritaanka isbeddelada sambabada ee cudurka AP, waxay sidoo kale si wax ku ool ah u muujin kartaa isdhexgalka endocrine visceral sida heerka dheef-shiid kiimikaadka iyo CCK.Waxa kale oo loo isticmaali karaa in lagu qiimeeyo baxnaaninta iyo soo kabashada unugyada dhaawacan ka dib joojinta walxaha khatarta ah.

5. Isticmaalka Caerulein cerulein (cerulein) iyo LPS si loo dhiso moodooyinka pankreatit waxay soo saari karaan saameynaha isdhexgalka, kii hore wuxuu kicin karaa enzymes pancreatic si uu u baabi'iyo xameetida, oo si joogto ah u dhaqaajiso unugyada bararka si ay u sii daayaan arrimaha caabuqa.Ka dib, LPS waxay carqaladaynaysaa jawaabta caadiga ah ee dhexdhexaadiyeyaasha bararka, sidaas awgeed waxay horumarinaysaa pankreatit gudaha gudaha sida dhacdo barar daran oo nidaamsan.

6. Cerulein waxaa loo isticmaali karaa si looga hortago xanuunka xameetida, calool-xanuunka kelyaha, iyo xanuunka claudication ee kala go'a.Guud ahaan waxaa loo arkaa inuu yahay kephalin antagonist endogenous.