Peptides-ka lidka ku ah jeermiska waxa ay asal ahaan ka soo jeedaan nidaamka difaaca cayayaanka, naasleyda, amfibiyada, iwm., waxayna inta badan ka mid yihiin afar qaybood:
1. Cecropin wuxuu asal ahaan ku jiray limfa difaaca ee Cecropiamoth, kaas oo inta badan laga helo cayayaanka kale, iyo peptides bakteeriyada la mid ah ayaa sidoo kale laga helaa xiidmaha doofaarka.Waxay caadi ahaan lagu gartaa gobolka N-terminal alkaline adag oo ay ku xigto jajab dheer oo biyo-bax ah.
2. Xenopus antimicrobial peptides (magainin) waxay ka soo jeedaan muruqyada iyo caloosha rahyada.Qaab dhismeedka xenopus antimicrobial peptides ayaa sidoo kale la ogaaday inuu yahay helical, gaar ahaan meelaha hydrophobic.Habaynta xenopus antipeptides ee lakabyada dufanka leh waxaa daraaseeyay N-ku calaamadeeyay wejiga adag ee NMR.Iyada oo ku saleysan isbeddelka kiimikaad ee resonance acylamine, helicesyada xenopus antipeptides waxay ahaayeen sagxadaha bilayer barbar socda, oo waxay isku dayi karaan inay sameeyaan qafis 13mm ah oo leh qaab-dhismeedka helical ee 30mm xilliyeed.
3. Defensin Difaaca peptides waxaa laga soo qaatay polykaryotic neutrophils bakaylaha polymacrophages aadanaha oo leh lobule dhamaystiran oo nukliyeer ah iyo unugyada xiidmaha ee xayawaanka.Koox ka mid ah peptides-ka difaaca bakteeriyada oo la mid ah peptides-ka difaaca naasleyda ayaa laga soo saaray cayayaanka, oo loo yaqaan "peptides difaaca cayayaanka".Si ka duwan peptides-ka difaaca naasleyda, peptides-ka difaaca cayayaanka ayaa kaliya ka firfircoon bakteeriyada Gram-positive.Xataa peptides difaaca cayayaanka waxaa ku jira lix haraaga Cys, laakiin habka disulfide isku xidhka midba midka kale waa ka duwan yahay.Habka isku xidhka buundada disulfide intramolecular ee qaabka bakteeriyada peptides ee laga soo saaray Drosophila melanogast waxay la mid tahay tan peptides-ka difaaca dhirta.Marka la eego xaaladaha crystal, peptides-ka difaaca ayaa loo soo bandhigay sida dimers.
4.Tachyplesin waxaa laga soo qaatay carsaanyo kabo faras, loo yaqaan horseshoecrab.Daraasadaha qaabeynta ayaa muujinaya in ay qaadato qaabeynta isku-laabashada B-ka-hortagga ah (boosyada 3-8, boosaska 11-16), kaas ooβ-xagal waxay ku xiran tahay midba midka kale (8-11 boos), iyo laba bonds disulfide ayaa la abuuray inta u dhaxaysa 7 iyo 12 boos, iyo inta u dhaxaysa 3 iyo 16 boos.Qaab dhismeedkan, hydrophobic amino acid wuxuu ku yaalaa hal dhinac oo ka mid ah diyaaradda, iyo lixda haraaga cationic waxay ka muuqdaan dabada molecule, sidaas darteed qaabdhismeedku sidoo kale waa biophilic.
Waxay soo socotaa in ku dhawaad dhammaan peptides-ka antimicrobial ay yihiin cationic dabeecadda, inkastoo ay ku kala duwan yihiin dhererka iyo dhererka;Dhamaadka sare, ha ahaato qaabka alfa-helical amaβ-laabi, qaab-dhismeedka bitropic waa sifada caadiga ah.
Waqtiga boostada: Abriil-20-2023