Nagu saabsan:
Peptide waa silsilad asiidhyo amino ah oo ku xidhan bonds peptide.Peptides waxay inta badan ku lug leeyihiin nidaaminta borotiinka, angiogenesis, kororka unugyada, melanogenesis, guuritaanka unugyada, iyo bararka.peptides bioactive ayaa si weyn loogu isticmaalay warshadaha qurxinta tobankii sano ee la soo dhaafay.Peptides waxay u baahan yihiin miisaan unug yar (> 500 Da), si loo yareeyo fidinta peptide ee u dhexeeya lakabyada epidermal, xasilooni sare iyo milanka.Sanadihii la soo dhaafay, bulshada sayniska ayaa soo saartay jajab yar oo xasilloon oo peptide synthetic taas oo kicisa wax soo saarka kolajka waxayna yareysaa laalaabkii wejiga iyo midabaynta.Trifluoroacetyl tripeptide-2 (isku xigxiga: TFA-Val-Try-Val-OH) synthesis tripeptide, oo loogu talagalay sidii matrix metalloproteinase iyo elastase inhibitor.Daraasadaha gudaha ee ku saabsan ilaalinta ECM ee trifluoro-acetyl tripeptide 2 (TT2), isku-darka proteoglycan ee isdhexgalka unugyada-matrixka, iyo saameynta progerin ee fibroblasts caadiga ah ee bini'aadamka ayaa dhawaan loo aqoonsaday inuu yahay isku-duwaha unugyada gacanta. caqli-galnimo.Natiijooyinku waxay soo jeedinayaan in trifluoroacetyl tripeptide 2 uu leeyahay tiro balaadhan oo ah sifooyinka gabowga.Tani waxay yaraynaysaa isku dhafka progerin, waxay kordhisaa wax soo saarka proteoglycan, waxayna yaraysaa kolajka, taas oo yaraynaysa laalaabyada iyo hagaajinta qallafsanaanta unugyada.Intaa waxaa dheer, ka-hortagga laalaabkeeda, laalaadkeeda ka-hortagga socodka iyo adkeynta maqaarka ayaa lagu qiimeeyay laba daraasadood oo waji kala qaybsan oo vitro ah.Trifluoroacetyl tripeptide 2 ayaa la muujiyay in ay saameyn horusocod leh ku leedahay laalaabkii, cidhiidhi, dabacsanaan, iyo hoos u dhac.
Trifluoroacetyl tripeptide-2 ma dib u dhigi kartaa gabowga?
Daraasaduhu waxay muujiyeen in suunka unuggu uu si dhow ula xiriiro Progerin.Iyadoo gabowga, presenilin ayaa ku urura in ka badan iyo in ka badan ee jirka, taasoo keenta cilladaha nukliyeerka iyo dhaawaca DNA, taasoo keenta noocyo kala duwan oo gabowga maqaarka.Trifluoroacetyl tripeptide-2 waa tripeptide firfircoon ee Elafin, oo ka soo jeeda elastase inhibitor.Waxay yaraynaysaa isku-dhafka Progerin waxayna wanaajisaa caajisnimada maqaarka, hoos u dhaca iyo laalaabyada.
Farsamaynta
1. Jooji isku-dhafka Progerin si loo daahiyo miyir-qabka gacanta.
2. Kor u qaadida wax soo saarka syndecan iyo dheeraynta nolosha unugga.
3. Jooji hawsha matrix metalloproteinases MMP1, MMP3 iyo MMP9, waxay yareeyaan burburka borotiinnada matrixka unugyada ka baxsan waxayna ilaaliyaan daacadnimadooda.
4. Jooji dhaqdhaqaaqa elastase, yaree xaalufka elastin, oo maqaarka ka dhig mid adag oo jilicsan.
Codsiga
Waxay ku habboon tahay dhammaan noocyada kala duwan ee ka hortagga laalaabka iyo gabowga, hagaajinta adkeynta, sawir-qaadista, daryeelka jirka ka dib dhalmada iyo qorraxda ka dib, iwm. Waxaa lagu daraa marxaladda ugu dambeysa ee wax soo saarka qurxinta.
Waqtiga boostada: Meey-22-2023