Falanqaynta farsamooyinka isku-dhafka peptide-sida

Farsamada isku dhafka Peptide-sida

Cilmi-baarista iyo horumarinta daawooyinka peptide ayaa si degdeg ah ugu koraya daawada.Si kastaba ha noqotee, horumarinta daawooyinka peptide waxay ku xaddidan yihiin sifooyinkooda.Tusaale ahaan, sababtoo ah dareenka gaarka ah ee loo yaqaan 'enzymatic hydrolysis', xasiloonida waa la dhimay, iyo kala duwanaanshiyaha is-beddelka stericku wuxuu keenaa bartilmaameed hoose oo gaar ah, hydrophobicity hooseeya, iyo la'aanta nidaam gaadiid oo gaar ah.Si looga adkaado peptides-ka, xalal badan oo la soo jeediyay iyo codsiga guusha ee hal nooc oo peptide ah ayaa ka mid ah.

Nooca peptide (magaca Ingiriisida: Peptoid) ama Poly - N - halkii laga isticmaali lahaa glycine (magaca Ingiriisiga: Poly real - N - beddelka glycine), waa xeryahooda peptide ee ka kooban peptide ee silsiladda ugu weyn.Silsiladda dhinaca kaarboonka ee alfa waxa ay gudbisaa silsiladda nitrogen ee ugu weyn halkii ay ka ahaan lahayd silsiladda dhinaca.Polypeptide-ka asalka ah, kooxda R ee silsiladda dhinaca amino acid waxay ka dhigan tahay 20 amino acids oo kala duwan, laakiin kooxda R waxay leeyihiin fursado badan oo peptoid ah.In peptide, peptide on silsiladda ugu weyn ee acids amino in alfa carbon nitrogen halkii wareejin silsilad dhinaca wareejinta silsiladda weyn.Waxaa habboon in la sheego in peptides guud ahaan aysan soo saarin qaab-dhismeedyada heerka sare ah ee la amray sida qaababka labaad ee peptides iyo borotiinka sababtoo ah la'aanta hydrogen ee nitrogen laf dhabarta.Ujeeddada ugu horreysa ee Peptide waa in la horumariyo peptide deggan oo ka difaaca dawooyinka molecule yar yar.

Falanqaynta farsamooyinka isku-dhafka peptide-sida

Habka peptide synthesis ayaa la soo bandhigay

Habka isku dhafka ah ee peptide-ka guud ahaan caanka ah waa habka isku-dhafka hoose ee uu ikhtiraacay RonZuckermann, mid kasta oo ka mid ah waxaa loo qaybiyaa laba tillaabo: Acylation iyo barokac.Acylation-ka, tillaabada ugu horreysa waa in la dhaqaajiyo aashitada haloacetic si ay uga fal-celiso amines-ka haray dhammaadka tallaabadii hore, inta badan diisopropyl-ka carbonized diimine.bromoaceticacid waxaa kiciyay diisopropylcarbodiimide."Dareen-celinta beddelka (falcelinta beddelka nukliyeerka ee bimolecular nucleophilic), amine, sida caadiga ah aasaasiga ah, waxay weerartaa halogen kale si uu u sameeyo glycine N-lagu beddelay."Dariiqa synthetic subunitary waxay isticmaashaa amines aasaasiga ah ee diyaarka ah si ay u soo saarto peptides, taas oo awood u siinaysa isku-darka kiimikaad ee peptides.

Kordhinta adag ee isku-dhafka peptides-ka fasalka waxay leedahay waayo-aragnimo qani ah, waxay ku siin kartaa noocyo kala duwan oo ah adeegga isku dhafka peptide.

Falanqaynta farsamooyinka isku-dhafka peptide-sida

Faa'iidada peptide noocan oo kale ah

Aad u deggan: peptoids-ka ayaa aad ugu deggan vivo marka loo eego peptides.

Xulasho badan: Peptoids waxay si fiican ugu habboon yihiin daraasadaha la isku daray ee helitaanka daroogada sababtoo ah noocyo badan oo kala duwan oo dhismooyinka polypeptide ah ayaa lagu heli karaa wax ka beddelka kooxda amino-ka ee laf dhabarta.

Waxtarka badan: Tirada badan ee qaababka peptoid-yada waxay ka dhigi kartaa peptoid doorasho wanaagsan ee habka iskaanka si dhakhso ah loo helo dhismayaal gaar ah oo ku xidhan borotiinnada.

Awood suuq oo badan: sifooyinka nooca peptide ha noqoto nooc ka mid ah horumarinta daroogada ayaa leh awood weyn.