ACTH (1-39) (jiirka jiirka)/77465-10-2/GT Peptide/Alaab-qeybiyaha Peptide

Sharaxaada 

ACTH 1-39 ee uruurinta 100 ilaa 400 nM wax saameyn ah kuma yeelan neurons-ka, halka ACTH ay ka hortagtay dhimashada excitotoxic neuronal ee ay keentay glutamate (100)μM), NMDA (1 mM), AMPA (50μM), iyo kainiki acid (25).Mikrometer).ACTH ee 400 nM waxay siisay ilaalin ku filan xaalad kasta.ACTH at 200 ama 400 nM neurons laga ilaaliyo quinolinic acid (25)μM)ACTH waxay kaloo ka hortagtay dhimashada unugyada oo ay sababeen 2μMH 2 O 2, taasoo keentay soo saarida noocyada ogsijiinta falcelinta (ROS), oo leh saameyn adag oo difaac ah oo 400 nM ah marka loo eego 200 nM.ACTH waxay bixisay difaac dhexdhexaad ah oo ka dhan ah siidaynta degdega ah ee nitric oxide (NO) ee NOC-12, laakiin kama hor istaagin sii deynta gaabis ah ee NOC-18.ACTH (200 ama 400 nM) waxay ka ilaalisaa neerfayaasha saamaynta cytotoxic ee crispsporin (10-20 nM), kicinta qadiimiga ah ee dhimashada unugyada iyada oo loo marayo apoptosis.ACTH waxay hoos u dhigtay dhimashada unugyada 80% ilaa 55%.

Tilmaamaha

Apperance: Caddaan ilaa budo ka baxsan-cad

Daahirnimada (HPLC):≥98.0%

Xumaanta Keliya:≤2.0%

Waxyaabaha Acetate (HPLC): 5.0%～12.0%

Waxyaabaha Biyaha ka kooban (Karl Fischer):≤10.0%

Waxa ku jira Peptide:≥80.0%

Xiritaanka iyo Rarista: Heerkulka hoose, baakaynta faakuumka, sax ilaa mg sida loogu baahdo.

Sida Loo Dalbado?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Ka dalbo online.Fadlan buuxi foomka dalabka onlaynka ah.

3. Bixi magaca peptide, CAS No. ama isku xigxiga, nadiifinta iyo wax ka beddelka haddii loo baahdo, tirada, iwm. waxaanu ku siin doonaa xigasho 2 saacadood gudahood.

4. Ku dalbo u hoggaansanaanta qandaraaska iibka ee si sax ah loo saxeexay iyo NDA(heshiiska aan shaacin) ama heshiis qarsoodi ah.

5. Waxaan si joogto ah u cusbooneysiin doonaa nidaamka horumarka waqtiga.

6. Gaadhida Peptide ee DHL, Fedex ama kuwa kale, iyo HPLC, MS, COA ayaa la bixin doona xamuulka.

7. Siyaasadda lacag-celinta waa la raacayaa haddii wax khilaaf ah tayadayada ama adeeggayaga.

8. Adeegga iibka kadib: Haddii macaamiisheena ay qabaan wax su'aalo ah oo ku saabsan peptide-kayaga inta lagu jiro tijaabada, fadlan xor ayaad u tahay inaad nala soo xiriirto waxaanan kaga jawaabi doonaa waqti gaaban.

Dhammaan alaabooyinka shirkadda waxaa loo isticmaalaa oo kaliya ujeedo cilmi baaris cilmiyeed, waxa's mamnuucday in ay si toos ah u isticmaalaan shakhsiyaad kasta oo jidhka bini'aadamka ah.

FAQ：

Dhammaadkee ayaa ugu fiican cilmi-baaristayda?

Sida caadiga ah, peptide-ku wuxuu ku dhamaanayaa N-terminal free amino group iyo kooxda karboxyl ee bilaashka ah ee C-terminal.Isku xigxiga peptide wuxuu inta badan matalaa isku xigxiga borotiinka hooyada.Si aad ugu dhowaato borotiinka hooyada, dhamaadka peptide inta badan wuxuu u baahan yahay in la xiro, taas oo ah, n-terminal acetylation iyo C-terminal amidation.Dib-u-habayntani waxay ka fogaanaysaa soo-bandhigista lacag-dhaafka ah, waxayna sidoo kale ka dhigaysaa mid awood badan si looga hortago ficil-celinta exonucliase, si peptide-ku u xasilo.

Waa kuwee polypeptides-ka sumaysan ee wax laga beddelay lagu soo saari karaa peptide Shiinaha?

Shirkaddayadu waxay bixisaa noocyo kala duwan oo summadaha peptide-ka la beddelay, sida acetylation, calaamadaynta biotin, beddelka fosforyaalka, wax ka beddelka fluorescence, sidoo kale waa lagu beddeli karaa iyadoo loo eegayo baahiyahaaga gaarka ah.

Sideed u milmi kartaa polypeptides?

Solubility polypeptide waxay inta badan ku xiran tahay qaab dhismeedkeeda aasaasiga ah iyo kan sare, dabeecadda calaamadda wax ka beddelka, nooca dareeraha iyo xoogga u dambeeya.Haddii peptide-ku aanu ku milmi biyaha, ultrasound ayaa kaa caawin kara in ay milaan.peptide aasaasiga ah, waxaa lagu talinayaa in lagu milo 10% acetic acid;peptides acidic ah, milmin leh 10% NH4HCO3 ayaa lagula talinayaa.Walxaha dabiiciga ah ayaa sidoo kale lagu dari karaa polypeptides aan la milmi karin.peptide-ku wuxuu ku milmay qadarka ugu yar ee dareeraha dabiiciga ah (tusaale, DMSO, DMF, khamriga isopropyl, methanol, iwm.).Waxaa aad loogu talinayaa in peptide-ka lagu milmo dareeraha organic marka hore ka dibna si tartiib ah loogu daro biyaha ama wax kale ilaa inta la doonayo.

Waa maxay shuruudaha ilaalinta ugu fiican?Intee in le'eg ayay peptide-du u xasilloon tahay?

Ka dib lyophilized, polypeptide waxay sameyn kartaa fluff ama budada flocculant, taas oo ka fogaan karta hoos u dhaca polypeptide.Shuruudaha kaydinta ee lagu taliyay: a.-20℃kaydinta ama deegaanka engegan b.Isku day inaad iska ilaaliso baraf soo noqnoqda - dhalaalid c.Isku day inaad iska ilaaliso kaydinta xaalada xalalka (budada la qaboojiyey waxaa lagu kaydin karaa baakado kala duwan si ay ugu haboonaato isticmaalka) d.Haddii ay tahay in lagu kaydiyo xalka, waxaa lagula talinayaa in lagu milmo peptides-ka biyaha nadiifka ah ee hoos yimaada xaaladaha aashitada daciifka ah oo ku kaydi -20℃.

Sidee loo qaadaa peptideyga?Waa maxay warbixinnada tijaabada ee la bixiyo?

Dhammaan polypeptides-ka la qaboojiyey waxaa badanaa lagu kaydiyaa weel gaar ah oo 2 ml ama 10ml ah oo wata xogta falanqaynta asalka ah iyo warbixinnada isku dhafan ee ka kooban macluumaadka muhiimka ah sida isku xigxiga, miisaanka unugyada, nadiifnimada, miisaanka, iyo tirada polypeptide-ka.

Waa maxay miisaanka saafiga ah?Waa maxay maadada peptide?

Ka dib marka lyophilized peptide uu guud ahaan qalafsan yahay oo u ekaado qalafsanaan, waxaa laga yaabaa inay weli ku jiraan xaddi biyo ah, dareere la isku daray iyo cusbo sababtoo ah sifooyinka peptide laftiisa.Tani macnaheedu maaha in nadiifinta peptide aysan ku filneyn, laakiin in nuxurka dhabta ah ee peptide uu hoos u dhaco 10% ilaa 30%.Miisaanka saafiga ah ee peptide-ku waa miisaanka dhabta ah ee peptide-ka oo laga jaray biyaha iyo ion protonated.Si loo hubiyo feejignaanta peptide-ka, walxaha aan peptide-ka ahayn waxay u baahan yihiin in laga saaro peptide cayriin.

Sidee bay nadiif u noqon kartaa peptide-ku?

Shirkaddayadu waxay siin kartaa heerar kala duwan oo nadiif ah macaamiisha si ay u kala doortaan, laga bilaabo cayriin ilaa> 99.9% nadiif ah.Marka loo eego baahida macaamiisha waxaan ku siin karnaa nadiifnimo> 99.9% ultra-pure polypeptide.